The Product

The DNAlyse Panel

One cheek swab, four areas of insight, 432 reports — for medical professionals, researchers and institutional clients.

432 reports in the panel. An individual report contains 422 (male) or 427 (female) — 15 reports are sex-specific. Ancestry is reported separately.

Area 01

Predisposition to common disease

107 reports

Quantified risk across multifactorial conditions where the genetic contribution is well characterised. Reported as risk relative to a reference population, with the contributing variants listed so the result can be interrogated rather than merely read.

Cardiovascular

  • Abdominal aortic aneurysm
  • Angina pectoris
  • Arterial hypertension
  • Atrial fibrillation
  • Coronary heart disease
  • Deep vein thrombosis
  • Heart failure
  • Intracranial aneurysm
  • Ischemic stroke
  • Myocardial infarction
  • Peripheral arterial disease
  • Pulmonary embolism
  • Varicose veins

Respiratory

  • Asthma
  • Chronic obstructive pulmonary disease (COPD)
  • Idiopathic pulmonary fibrosis
  • Sarcoidosis
  • Allergic rhinitis

Autoimmune

  • Addison's disease
  • Diabetes mellitus type 1
  • Graves' disease
  • Hashimoto's thyroiditis
  • Juvenile idiopathic arthritis
  • Multiple sclerosis
  • Primary biliary cirrhosis
  • Rheumatoid arthritis
  • Systemic lupus erythematosus
  • Systemic sclerosis
  • Vitiligo

Neurological and psychiatric

  • Alzheimer's disease
  • Amyotrophic lateral sclerosis
  • Anxiety
  • Bipolar disorder
  • Depression
  • Headaches
  • Migraines
  • Narcolepsy
  • Parkinson's disease
  • Restless legs syndrome
  • Schizophrenia

Gastrointestinal and hepatic

  • Abdominal hernia
  • Barrett's esophagus
  • Colon polyp
  • Crohn's disease
  • Diaphragmatic hernia
  • Diverticulosis / diverticulitis
  • Gallstones
  • Gastroesophageal reflux disease
  • Haemorrhoidal disease
  • Inguinal hernia
  • Non-alcoholic fatty liver disease
  • Non-celiac intestinal malabsorption
  • Ulcerative colitis

Oncological

  • Basal cell carcinoma
  • Chronic lymphocytic leukemia
  • Colorectal cancer
  • Cutaneous malignant melanoma
  • Endometrial cancer
  • Glioblastoma
  • Glioma
  • Lung cancer
  • Monoclonal gammopathy of uncertain significance
  • Multiple myeloma
  • Myeloproliferative neoplasms
  • Neuroblastoma
  • Non-medullary thyroid cancer
  • Oral cavity and oropharyngeal cancer
  • Pancreatic cancer
  • Prostate cancer
  • Squamous cell carcinoma of the skin
  • Testicular germ cell cancer

Endocrine and metabolic

  • Diabetes mellitus type 2
  • Hypercholesterolemia
  • Hyperlipidemia
  • Hypothyroidism
  • Non-toxic multinodular goiter

Musculoskeletal

  • Adolescent idiopathic scoliosis
  • Carpal tunnel syndrome
  • Dupuytren's disease
  • Fasciitis
  • General osteoarthritis
  • Gout
  • Hallux valgus
  • Osteoarthritis of the hip
  • Osteoarthritis of the knee
  • Osteoporosis
  • Spinal canal stenosis

Dermatological

  • Actinic keratosis
  • Atopic dermatitis
  • Psoriasis

Ophthalmological

  • Age-related macular degeneration
  • Cataracts
  • Keratoconus
  • Macular telangiectasia type 2
  • Open angle glaucoma

Urological and renal

  • Benign prostatic hyperplasia
  • Chronic kidney disease
  • Urolithiasis

Gynaecological and obstetric

  • Endometriosis
  • Intrahepatic cholestasis of pregnancy
  • Polycystic ovary syndrome
  • Uterine leiomyoma
  • Uterine prolapse

ENT and craniofacial

  • Age-related hearing impairment
  • Sensorineural hearing loss
  • Nasal polyps
  • Non-syndromic cleft lip
Area 02

Inherited conditions and carrier status

102 reports

Monogenic conditions across recessive and dominant inheritance patterns. Carrier findings are reported as carrier status without implication of phenotype — relevant to reproductive counselling and to family-history work.

Metabolic and lysosomal disorders

  • Acute intermittent porphyria (HMBS gene)
  • Alpha-1 antitrypsin deficiency
  • Alpha-mannosidosis
  • Biotinidase deficiency
  • Classical homocystinuria due to CBS deficiency
  • Congenital disorder of glycosylation type 1a (PMM2 gene)
  • Cystinosis
  • D-bifunctional protein deficiency
  • Dihydrolipoamide dehydrogenase deficiency
  • Familial hyperinsulinism (ABCC8-related)
  • GRACILE syndrome
  • Gaucher disease
  • Glutaric acidemia type 1
  • Glutaric acidemia type 2
  • Glycogen storage disease type 1A (von Gierke disease)
  • Glycogen storage disease type 1B
  • Glycogen storage disease type 3
  • Glycogenosis type 2 (Pompe disease)
  • Glycogenosis type 5 (McArdle's disease)
  • Hereditary fructose intolerance
  • Hereditary hemochromatosis type 1 (HFE gene)
  • Homocystinuria due to MTHFR deficiency
  • Leigh syndrome, French-Canadian type (LSFC)
  • Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency
  • Maple syrup urine disease type 1B
  • Medium-chain acyl-CoA dehydrogenase deficiency (MCADD)
  • Metachromatic leukodystrophy
  • Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
  • Mucolipidosis II and III alpha/beta
  • Mucolipidosis type IV (MCOLN1 gene)
  • Niemann-Pick disease type A and B
  • Phenylketonuria
  • Refsum disease
  • Salla disease
  • Short-chain acyl-CoA dehydrogenase deficiency (SCADD)
  • Tay-Sachs disease
  • Tyrosinemia type I
  • Very long-chain acyl-CoA dehydrogenase deficiency (VLCADD)
  • Wilson disease
  • Zellweger syndrome
  • cblA type methylmalonic aciduria
  • cblB type methylmalonic aciduria

Neurodevelopmental and neurological

  • ARSACS (autosomal recessive spastic ataxia of Charlevoix-Saguenay)
  • Agenesis of the corpus callosum with peripheral neuropathy (ACCPN)
  • Canavan disease
  • Familial advanced sleep phase syndrome (FASPS)
  • Familial dysautonomia (Riley-Day syndrome)
  • Leukoencephalopathy with vanishing white matter
  • Neuronal ceroid lipofuscinosis type 1 (PPT1 gene)
  • Neuronal ceroid lipofuscinosis type 3 (CLN3 gene)
  • Neuronal ceroid lipofuscinosis type 5 (CLN5 gene)
  • Neuronal ceroid lipofuscinosis type 6 (CLN6 gene)
  • Neuronal ceroid lipofuscinosis type 7 (MFSD8 gene)
  • Pontocerebellar hypoplasia types 2A, 4 and 5 (TSEN54 gene)
  • Pyridoxine-dependent epilepsy

Cancer predisposition syndromes

  • Birt-Hogg-Dubé syndrome
  • Bloom syndrome
  • Familial adenomatous polyposis
  • Familial breast cancer (BRCA1 and BRCA2 genes)
  • Hamartoma tumor syndrome (PTEN gene)
  • Li-Fraumeni syndrome
  • Lynch syndrome
  • Multiple endocrine neoplasia 2B
  • Neurofibromatosis type I

Cardiovascular disorders

  • Brugada syndrome
  • Dilated cardiomyopathy 1A (LMNA gene)
  • Familial hypercholesterolemia
  • Familial hypertrophic cardiomyopathy (HCM)
  • Transthyretin amyloidosis (TTR gene)

Blood disorders

  • Beta thalassemia
  • Fanconi anemia (FANCC gene)
  • Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency)
  • Hemophilia A
  • Pyruvate kinase deficiency
  • von Willebrand disease

Muscle and movement disorders

  • Autosomal recessive limb-girdle muscular dystrophy
  • Congenital muscular alpha-dystroglycanopathy and Walker-Warburg syndrome
  • Congenital myasthenic syndrome (RAPSN gene)
  • Hypokalemic periodic paralysis
  • Malignant hyperthermia

Visual disorders

  • Achromatopsia
  • Autosomal recessive retinitis pigmentosa
  • Congenital stationary night blindness
  • Oculocutaneous albinism (OCA2 gene)
  • Oculocutaneous albinism (TYR gene)
  • Peters plus syndrome
  • Usher syndrome

Hearing disorders

  • Non-syndromic mitochondrial hearing loss
  • Non-syndromic hearing loss and deafness, DFNB1
  • Pendred syndrome

Skeletal and connective tissue

  • Diastrophic dysplasia
  • Ehlers-Danlos syndrome (EDS)
  • Hypophosphatasia
  • Rhizomelic chondrodysplasia punctata type 1

Dermatological conditions

  • Junctional epidermolysis bullosa
  • Sjögren-Larsson syndrome

Respiratory, renal, hepatic and other

  • Cystic fibrosis
  • Autosomal recessive polycystic kidney disease
  • Primary hyperoxaluria type 1 (PH1)
  • Primary hyperoxaluria type 2 (PH2)
  • Dubin-Johnson syndrome
  • Familial Mediterranean fever
Area 03

Pharmacogenomics

95 reports

Metabolism and response profiles across commonly prescribed classes, reported against established guideline categories so findings map onto prescribing frameworks clinicians already use.

Pharmacogenomic results inform prescribing decisions; they do not replace them. No patient should start, stop, or alter the dose of any medication on the basis of this report without consulting their prescribing physician.

Dosage guidance · 58

Antidepressants

  • Amitriptyline
  • Citalopram
  • Clomipramine
  • Desipramine
  • Doxepin
  • Escitalopram
  • Fluvoxamine
  • Imipramine
  • Nortriptyline
  • Paroxetine
  • Sertraline
  • Trimipramine
  • Venlafaxine
  • Vortioxetine

Antipsychotics

  • Aripiprazole
  • Brexpiprazole
  • Haloperidol
  • Iloperidone
  • Pimozide
  • Quetiapine
  • Risperidone
  • Zuclopenthixol

Statins and lipid-lowering

  • Atorvastatin
  • Fluvastatin
  • Lovastatin
  • Pitavastatin
  • Pravastatin
  • Rosuvastatin
  • Simvastatin
  • Statins — dosage and risk of myopathy

Analgesics and anti-inflammatories

  • Celecoxib
  • Codeine
  • Flurbiprofen
  • Hydrocodone
  • Ibuprofen
  • Lornoxicam
  • Meloxicam
  • Piroxicam
  • Tenoxicam
  • Tramadol

Anticonvulsants

  • Brivaracetam
  • Carbamazepine
  • Phenytoin

Proton-pump inhibitors

  • Lansoprazole, dexlansoprazole
  • Omeprazole
  • Pantoprazole

Cardiovascular agents

  • Clopidogrel
  • Flecainide
  • Metoprolol

Antineoplastics and immunosuppressants

  • Fluorouracil, capecitabine
  • Tacrolimus
  • Thioguanine, azathioprine, mercaptopurine

Other agents

  • Allopurinol
  • Amifampridine
  • Atomoxetine
  • Pitolisant
  • Siponimod
  • Voriconazole

Adverse reaction risk · 28

Antibiotics and anti-infectives

  • Aminoglycoside antibiotics
  • Flucloxacillin
  • Flucytosine
  • Isoniazid

Antiretrovirals

  • Abacavir
  • Atazanavir
  • Efavirenz

Anticoagulants

  • Acenocoumarol, phenprocoumon
  • Fluindione
  • Warfarin

Antineoplastics

  • Cisplatin
  • Daunorubicin, doxorubicin
  • Docetaxel
  • Irinotecan
  • Methotrexate
  • Nilotinib

Antidepressants and antipsychotics

  • Mirtazapine
  • Olanzapine
  • Selective serotonin reuptake inhibitors (SSRIs)

Anxiolytics, sedatives and anaesthesia

  • Clobazam
  • Diazepam
  • Inhalational anaesthetics and succinylcholine
  • Mivacurium and succinylcholine

Anti-epileptics

  • Valproic acid

Other agents

  • Eliglustat
  • Hormonal contraceptives
  • Propafenone
  • G6PD deficiency and adverse drug reactions

Expected efficacy · 9

Cystic fibrosis modulators

  • Ivacaftor
  • Lumacaftor + ivacaftor

Analgesics

  • Fentanyl

Antineoplastics and immunomodulators

  • Tamoxifen
  • Methotrexate in rheumatoid arthritis

Antivirals

  • Peginterferon alfa-2a / alfa-2b and ribavirin

Other agents

  • Hydrochlorothiazide
  • Olanzapine
  • Gonadotrophins and ovulation stimulants
Area 04

Traits, wellness and ancestry

128 reports

Nutrient and micronutrient metabolism, caffeine and alcohol processing, physical and sensory traits, and biogeographical ancestry with maternal and paternal lineage assignment.

Nutrition, diet and metabolism

  • Antioxidant capacity (GPX1 and CAT genes)
  • Basal metabolic rate
  • Bitter taste perception
  • Body fat percentage
  • Body mass index
  • Caffeine and anxiety
  • Caffeine and sports performance
  • Caffeine dependence after prolonged consumption
  • Celiac disease predisposition
  • Farmer-hunter profile
  • Food intake control
  • Genetic predisposition to peanut allergy
  • Histamine intolerance
  • Lactose intolerance
  • Long-chain omega fatty acid levels
  • Preference for sweets
  • Prediction of visceral adipose tissue
  • Alcohol dependence after prolonged consumption
  • Alcohol flush reaction
  • Nicotine dependence after prolonged consumption

Vitamins, minerals and micronutrients

  • Vitamin A (beta carotene) levels
  • Vitamin B12 levels
  • Vitamin C levels
  • Vitamin D levels
  • Vitamin E levels
  • Calcium levels
  • Serum phosphate levels
  • Liver iron levels
  • Gene MTHFR
  • Gene MTR
  • Gene MTRR

Cardiometabolic and laboratory markers

  • Apolipoprotein A1 levels
  • Apolipoprotein B levels
  • Blood glucose
  • Glycated hemoglobin levels
  • HDL cholesterol levels
  • LDL cholesterol levels
  • Systolic blood pressure levels
  • Diastolic blood pressure levels
  • Resting heart rate
  • QT intervals
  • C-reactive protein levels
  • Galectin-3 levels
  • Resistin levels
  • Selectin E levels
  • Cathepsin D levels
  • Creatinine levels
  • Urate levels
  • Alanine aminotransferase levels
  • Aspartate aminotransferase levels
  • Alkaline phosphatase levels
  • Gamma glutamyl transferase levels
  • Bilirubin levels
  • Serum albumin levels
  • Total serum protein levels
  • Thyroid function (TSH levels)
  • Estradiol levels
  • Sex hormone regulation (SHBG)
  • Red blood cell count
  • White blood cell count
  • Lymphocyte count
  • Monocyte count
  • Neutrophil count
  • Eosinophil count
  • Spleen volume
  • Persistence of fetal hemoglobin
  • Blood group ABO/Rh
  • Blood coagulation, factor V Leiden and 20210G-A
  • Secretor status and ABH antigens (FUT2 gene)
  • HLA-B27 antigen
  • Duffy antigen and malaria resistance
  • CCR5-delta32 and susceptibility to HIV infection

Fitness, musculoskeletal and recovery

  • Bone mineral density
  • Muscle endurance
  • Exercise-induced muscle damage (initial phase)
  • Exercise-induced muscle damage (second phase)
  • Exercise-induced muscle damage (regeneration capacity)
  • Myoadenylate deaminase (AMPD1 gene)
  • Tendinopathies in the lower extremities
  • Tendinopathies in the upper extremities
  • Heat production in response to cold
  • Lung function (exhaled air volume)
  • Usual walking pace
  • Height
  • Birth weight
  • Telomere length
  • Epigenetic aging

Oral, dermatological and sensory traits

  • Dental caries and periodontitis
  • Permanent tooth eruption
  • Tooth morphology
  • Mouth ulcers
  • Acne vulgaris
  • Facial aging
  • Skin melanin levels
  • Hair colour
  • Hair texture
  • Probability of having red hair
  • Male pattern baldness
  • Ear lobe type
  • Earwax type and armpit odour
  • Nasion prominence
  • Eye clarity
  • Pigmented rings on the iris
  • Corneal curvature
  • Corneal hysteresis
  • Intraocular pressure
  • Sense of smell
  • Asparagus odour detection
  • Photic sneeze reflex
  • Intensity of itching due to mosquito bites

Sleep, behaviour and neurocognitive traits

  • Sleep duration
  • Insomnia
  • Probability of snoring
  • Morning circadian rhythm (morning person)
  • Cognitive ability
  • Mental agility
  • Neuroticism
  • Risk tendency
  • Gene COMT
  • Left-handedness (left lateral)
  • Frequency of bowel movements
  • Early menopause
  • Menarche
  • Prostate specific antigen (PSA) levels
  • CYP2C19 metabolizer profile
  • CYP2C9 metabolizer profile
  • CYP2D6 metabolizer profile
  • CYP3A5 metabolizer profile

Ancestry

Origins and lineage

  • Biogeographical ancestry across global reference populations
  • How ancestry is distributed across populations
  • Maternal haplogroup assignment
  • Paternal haplogroup assignment
  • Proportion of Neanderthal-derived DNA